Endocrinology and Metabolism

Hyun Yee Cho (Cho HY)

2 Articles

Langerhans Cell Histiocytosis in the Thyroid and Draining Lymph Nodes: A Case Report.: Dong Hae Chung, Seung Yeon Ha, Hyun Yee Cho, Na Rae Kim, Jung Suk An, Young Don Lee, Sanghui Park; Endocrinol Metab. 2012;27(2):138-141. Published online June 20, 2012; DOI: https://doi.org/10.3803/EnM.2012.27.2.138

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A 53-year-old woman was presented with several 0.3-0.6 cm-sized nodules within the right lobe of the thyroid. Histologic sections of the thyroid demonstrated multiple papillary microcarcinomas in the background of lymphocytic thyroiditis, with a small focus of Langerhans cell histiocytosis (LCH). Small LCH nodules were also found in the draining cervical lymph nodes. Although the association of LCH with papillary thyroid carcinoma in the thyroid has been reported, their co-existence with LCH in the draining lymph nodes is very rare.

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BRAF gene mutations in synchronous papillary thyroid carcinoma and Langerhans cell histiocytosis co-existing in the thyroid gland: a case report and literature review
Mohammad A. Al Hamad, Hassan M. Albisher, Weam R. Al Saeed, Ahmed T. Almumtin, Fatimah M. Allabbad, Mohammed A. Shawarby
BMC Cancer.2019;[Epub] CrossRef
Adult Multisystem Langerhans Cell Histiocytosis Presenting with Central Diabetes Insipidus Successfully Treated with Chemotherapy
Jung-Eun Choi, Hae Ri Lee, Jung Hun Ohn, Min Kyong Moon, Juri Park, Seong Jin Lee, Moon-Gi Choi, Hyung Joon Yoo, Jung Han Kim, Eun-Gyoung Hong
Endocrinology and Metabolism.2014; 29(3): 394. CrossRef

Laparoscopically Resected Composite Pheochromocytoma-Ganglioneuroma.: Na Rae Kim, Taeeun Kim, Jeong Nam Lee, Young Sil Eom, Dong Hae Chung, Sanghui Park, Hyun Yee Cho; Endocrinol Metab. 2011;26(4):340-344. Published online December 1, 2011; DOI: https://doi.org/10.3803/EnM.2011.26.4.340

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Abstract PDF

Composite pheochromocytoma-ganglioneuroma is one of the mixed neuroendocrine-neural tumors composed of pheochromocytoma and other neural crest derivatives. To date, less than 50 cases of composite pheochromocytoma have been reported, and about 70% of the accompanying tumors were ganglioneuromas. Here, we describe six cases of composite pheochromocytoma-ganglioneuromas in five men and one woman, aged 33 to 64. The size of the tumors ranged from 3.0 to 11.0 cm, and four out of the six presented with intermittent onset of hypertension, palpitation, or dizziness. Microscopically, each tumor was composed of large pleomorphic shaped chromaffin cells arranged in the Zellballen patterns characteristic of pheochromocytoma, and they were mixed with clusters of mature ganglion cells and bundles of spindle-shaped Schwann cells characteristic of ganglioneuroma of variable proportions. All were successfully treated laparoscopically, and none were associated with multiple endocrine neoplasm syndrome or neurofibromatosis. Preoperative diagnosis of a composite pheochromocytoma-ganglioneuroma is impossible because of the low incidence rate, and the radiological findings and symptoms are similar to those of typical pheochromocytomas. Although the significance of microscopic detection of the nonpheochromocytoma component from pheochromocytoma has not yet been clarified, microscopic identification of the composite pheochromocytoma-ganglioneuroma is important because cumulative cases are used in an effort to predict the behavior of this composite tumor.

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Imaging of rare medullary adrenal tumours in adults
C.A. Maciel, Y.Z. Tang, G. Coniglio, A. Sahdev
Clinical Radiology.2016; 71(5): 484. CrossRef

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